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Motor Neuron Gene Therapy: Lessons from Spinal Muscular Atrophy for Amyotrophic Lateral Sclerosis

Spinal muscular atrophy (SMA) and amyotrophic lateral sclerosis (ALS) are severe nervous system diseases characterized by the degeneration of lower motor neurons. They share a number of additional pathological, cellular, and genetic parallels suggesting that mechanistic and clinical insights into on...

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Detalhes bibliográficos
Publicado no:Front Mol Neurosci
Main Authors: Tosolini, Andrew P., Sleigh, James N.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5725447/
https://ncbi.nlm.nih.gov/pubmed/29270111
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2017.00405
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