Increased Conformational Flexibility of a Macrocycle–Receptor Complex Contributes to Reduced Dissociation Rates

Constraining a peptide in its bioactive conformation by macrocyclization represents a powerful strategy to design modulators of challenging biomolecular targets. This holds particularly true for the development of inhibitors of protein‐protein interactions which often involve interfaces lacking defi...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Chemistry
Hauptverfasser: Glas, Adrian, Wamhoff, Eike‐Christian, Krüger, Dennis M., Rademacher, Christoph, Grossmann, Tom N.
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2017
Schlagworte:
Communications
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5724689/
https://ncbi.nlm.nih.gov/pubmed/28777495
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.201702776
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