Structure-Based Design of Non-natural Macrocyclic Peptides That Inhibit Protein–Protein Interactions

[Image: see text] Macrocyclic peptides can interfere with challenging biomolecular targets including protein–protein interactions. Whereas there are various approaches that facilitate the identification of peptide-derived ligands, their evolution into higher affinity binders remains a major hurdle....

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Veröffentlicht in:J Med Chem
Hauptverfasser: Krüger, Dennis M., Glas, Adrian, Bier, David, Pospiech, Nicole, Wallraven, Kerstin, Dietrich, Laura, Ottmann, Christian, Koch, Oliver, Hennig, Sven, Grossmann, Tom N.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Chemical Society 2017
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5682607/
https://ncbi.nlm.nih.gov/pubmed/29028171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.7b01221
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