Constraining an Irregular Peptide Secondary Structure through Ring‐Closing Alkyne Metathesis

Macrocyclization can be used to constrain peptides in their bioactive conformations, thereby supporting target affinity and bioactivity. In particular, for the targeting of challenging protein–protein interactions, macrocyclic peptides have proven to be very useful. Available approaches focus on the...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:Chembiochem
Autori principali: Cromm, Philipp M., Wallraven, Kerstin, Glas, Adrian, Bier, David, Fürstner, Alois, Ottmann, Christian, Grossmann, Tom N.
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2016
Soggetti:
Communications
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5096054/
https://ncbi.nlm.nih.gov/pubmed/27596722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201600362
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