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Orthogonal ring-closing alkyne and olefin metathesis for the synthesis of small GTPase-targeting bicyclic peptides

Bicyclic peptides are promising scaffolds for the development of inhibitors of biological targets that proved intractable by typical small molecules. So far, access to bioactive bicyclic peptide architectures is limited due to a lack of appropriate orthogonal ring-closing reactions. Here, we report...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Cromm, Philipp M., Schaubach, Sebastian, Spiegel, Jochen, Fürstner, Alois, Grossmann, Tom N., Waldmann, Herbert
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4834642/
https://ncbi.nlm.nih.gov/pubmed/27075966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms11300
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