Constraining an Irregular Peptide Secondary Structure through Ring‐Closing Alkyne Metathesis

Macrocyclization can be used to constrain peptides in their bioactive conformations, thereby supporting target affinity and bioactivity. In particular, for the targeting of challenging protein–protein interactions, macrocyclic peptides have proven to be very useful. Available approaches focus on the...

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Dades bibliogràfiques
Publicat a:Chembiochem
Autors principals: Cromm, Philipp M., Wallraven, Kerstin, Glas, Adrian, Bier, David, Fürstner, Alois, Ottmann, Christian, Grossmann, Tom N.
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2016
Matèries:
Communications
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5096054/
https://ncbi.nlm.nih.gov/pubmed/27596722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201600362
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