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Glutamate Racemase Dimerization Inhibits Dynamic Conformational Flexibility and reduces Catalytic Rates
Glutamate racemase (RacE) is a bacterial enzyme that converts L-glutamate to D-glutamate, an essential precursor for peptidoglycan synthesis. In prior work, we have shown that both isoforms co-crystallize with D-glutamate as dimers, and the enzyme is in a closed conformation with limited access to t...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2734939/ https://ncbi.nlm.nih.gov/pubmed/19552402 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi9005072 |
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