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Elucidating the catalytic power of glutamate racemase by investigating a series of covalent inhibitors

The application of covalent inhibitors has experienced a renaissance within drug discovery programs in the last decade. To leverage the superior potency and drug target residence time of covalent inhibitors, there have been extensive efforts to develop highly specific covalent modifications to reduc...

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Detalhes bibliográficos
Publicado no:ChemMedChem
Main Authors: Vance, Nicholas R., Witkin, Katie R., Rooney, Patrick W., Li, Yalan, Pope, Marshall, Spies, M. Ashley
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6581216/
https://ncbi.nlm.nih.gov/pubmed/30264520
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201800592
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