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Elucidating the catalytic power of glutamate racemase by investigating a series of covalent inhibitors

The application of covalent inhibitors has experienced a renaissance within drug discovery programs in the last decade. To leverage the superior potency and drug target residence time of covalent inhibitors, there have been extensive efforts to develop highly specific covalent modifications to reduc...

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Publicat a:ChemMedChem
Autors principals: Vance, Nicholas R., Witkin, Katie R., Rooney, Patrick W., Li, Yalan, Pope, Marshall, Spies, M. Ashley
Format: Artigo
Idioma:Inglês
Publicat: 2018
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6581216/
https://ncbi.nlm.nih.gov/pubmed/30264520
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201800592
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