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Exploiting Enzyme Plasticity in Virtual Screening: High Efficiency Inhibitors of Glutamate Racemase
[Image: see text] Glutamate racemase is an attractive antimicrobial drug target. Virtual screening using a transition-state conformation of the enzyme resulted in the discovery of several μM competitive inhibitors, dissimilar from current amino acid-like inhibitors, providing novel scaffolds for dru...
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| Autori principali: | , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Chemical Society
2009
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| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2903749/ https://ncbi.nlm.nih.gov/pubmed/20634968 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml900005b |
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