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Biosynthesis of a Novel Glutamate Racemase Containing a Site-Specific 7-Hydroxycoumarin Amino Acid: Enzyme–Ligand Promiscuity Revealed at the Atomistic Level
[Image: see text] Glutamate racemase (GR) catalyzes the cofactor independent stereoinversion of l- to d-glutamate for biosynthesis of bacterial cell walls. Because of its essential nature, this enzyme is under intense scrutiny as a drug target for the design of novel antimicrobial agents. However, t...
Gorde:
| Argitaratua izan da: | ACS Cent Sci |
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| Egile Nagusiak: | , , |
| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
American Chemical Society
2015
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| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4626791/ https://ncbi.nlm.nih.gov/pubmed/26539562 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acscentsci.5b00211 |
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