A retractable lid in lecithin:cholesterol acyltransferase provides a structural mechanism for activation by apolipoprotein A-I

Lecithin:cholesterol acyltransferase (LCAT) plays a key role in reverse cholesterol transport by transferring an acyl group from phosphatidylcholine to cholesterol, promoting the maturation of high-density lipoproteins (HDL) from discoidal to spherical particles. LCAT is activated through an unknown...

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Vydáno v:J Biol Chem
Hlavní autoři: Manthei, Kelly A., Ahn, Joomi, Glukhova, Alisa, Yuan, Wenmin, Larkin, Christopher, Manett, Taylor D., Chang, Louise, Shayman, James A., Axley, Milton J., Schwendeman, Anna, Tesmer, John J. G.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2017
Témata:
Protein Structure and Folding
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5724016/
https://ncbi.nlm.nih.gov/pubmed/29030428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.802736
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