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Arginine 123 of apolipoprotein A-I is essential for lecithin:cholesterol acyltransferase activity

ApoA-I activates LCAT that converts lipoprotein cholesterol to cholesteryl ester (CE). Molecular dynamic simulations suggested earlier that helices 5 of two antiparallel apoA-I molecules on discoidal HDL form an amphipathic tunnel for migration of acyl chains and unesterified cholesterol to the acti...

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Bibliographic Details
Published in:J Lipid Res
Main Authors: Gorshkova, Irina N., Mei, Xiaohu, Atkinson, David
Format: Artigo
Language:Inglês
Published: The American Society for Biochemistry and Molecular Biology 2018
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5794428/
https://ncbi.nlm.nih.gov/pubmed/29208698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M080986
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