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Arginine 123 of apolipoprotein A-I is essential for lecithin:cholesterol acyltransferase activity
ApoA-I activates LCAT that converts lipoprotein cholesterol to cholesteryl ester (CE). Molecular dynamic simulations suggested earlier that helices 5 of two antiparallel apoA-I molecules on discoidal HDL form an amphipathic tunnel for migration of acyl chains and unesterified cholesterol to the acti...
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| 出版年: | J Lipid Res |
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| 主要な著者: | , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
The American Society for Biochemistry and Molecular Biology
2018
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5794428/ https://ncbi.nlm.nih.gov/pubmed/29208698 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M080986 |
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