Numb prevents a complete epithelial–mesenchymal transition by modulating Notch signalling

Epithelial–mesenchymal transition (EMT) plays key roles during embryonic development, wound healing and cancer metastasis. Cells in a partial EMT or hybrid epithelial/mesenchymal (E/M) phenotype exhibit collective cell migration, forming clusters of circulating tumour cells—the primary drivers of me...

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Bibliografiske detaljer
Udgivet i:J R Soc Interface
Main Authors: Bocci, Federico, Jolly, Mohit K., Tripathi, Satyendra C., Aguilar, Mitzi, Hanash, Samir M., Levine, Herbert, Onuchic, José N.
Format: Artigo
Sprog:Inglês
Udgivet: The Royal Society 2017
Fag:
Life Sciences–Physics interface
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5721160/
https://ncbi.nlm.nih.gov/pubmed/29187638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rsif.2017.0512
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