Numb prevents a complete epithelial–mesenchymal transition by modulating Notch signalling

Epithelial–mesenchymal transition (EMT) plays key roles during embryonic development, wound healing and cancer metastasis. Cells in a partial EMT or hybrid epithelial/mesenchymal (E/M) phenotype exhibit collective cell migration, forming clusters of circulating tumour cells—the primary drivers of me...

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Detalhes bibliográficos
Publicado no:J R Soc Interface
Main Authors: Bocci, Federico, Jolly, Mohit K., Tripathi, Satyendra C., Aguilar, Mitzi, Hanash, Samir M., Levine, Herbert, Onuchic, José N.
Formato: Artigo
Idioma:Inglês
Publicado em: The Royal Society 2017
Assuntos:
Life Sciences–Physics interface
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5721160/
https://ncbi.nlm.nih.gov/pubmed/29187638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rsif.2017.0512
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