Inhibition of group-I metabotropic glutamate receptors protects against prion toxicity

Prion infections cause inexorable, progressive neurological dysfunction and neurodegeneration. Expression of the cellular prion protein PrP(C) is required for toxicity, suggesting the existence of deleterious PrP(C)-dependent signaling cascades. Because group-I metabotropic glutamate receptors (mGlu...

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Detalhes bibliográficos
Publicado no:PLoS Pathog
Main Authors: Goniotaki, Despoina, Lakkaraju, Asvin K. K., Shrivastava, Amulya N., Bakirci, Pamela, Sorce, Silvia, Senatore, Assunta, Marpakwar, Rajlakshmi, Hornemann, Simone, Gasparini, Fabrizio, Triller, Antoine, Aguzzi, Adriano
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5720820/
https://ncbi.nlm.nih.gov/pubmed/29176838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1006733
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