Inhibition of group-I metabotropic glutamate receptors protects against prion toxicity

Prion infections cause inexorable, progressive neurological dysfunction and neurodegeneration. Expression of the cellular prion protein PrP(C) is required for toxicity, suggesting the existence of deleterious PrP(C)-dependent signaling cascades. Because group-I metabotropic glutamate receptors (mGlu...

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Détails bibliographiques
Publié dans:PLoS Pathog
Auteurs principaux: Goniotaki, Despoina, Lakkaraju, Asvin K. K., Shrivastava, Amulya N., Bakirci, Pamela, Sorce, Silvia, Senatore, Assunta, Marpakwar, Rajlakshmi, Hornemann, Simone, Gasparini, Fabrizio, Triller, Antoine, Aguzzi, Adriano
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2017
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5720820/
https://ncbi.nlm.nih.gov/pubmed/29176838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1006733
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