Soluble dimeric prion protein ligand activates Adgrg6 receptor but does not rescue early signs of demyelination in PrP-deficient mice

The adhesion G-protein coupled receptor Adgrg6 (formerly Gpr126) is instrumental in the development, maintenance and repair of peripheral nervous system myelin. The prion protein (PrP) is a potent activator of Adgrg6 and could be used as a potential therapeutic agent in treating peripheral demyelina...

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Veröffentlicht in:PLoS One
Hauptverfasser: Henzi, Anna, Senatore, Assunta, Lakkaraju, Asvin K. K., Scheckel, Claudia, Mühle, Jonas, Reimann, Regina, Sorce, Silvia, Schertler, Gebhard, Toyka, Klaus V., Aguzzi, Adriano
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2020
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7660510/
https://ncbi.nlm.nih.gov/pubmed/33180885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0242137
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