The prion protein is an agonistic ligand of the G protein-coupled receptor Gpr126/Adgrg6

Ablation of the cellular prion protein PrP(C) leads to a chronic demyelinating polyneuropathy (CDP) affecting Schwann cells. Neuron-restricted PrP(C) expression prevents the disease(1), suggesting that it acts in trans through an unidentified Schwann cell receptor. We found that the cAMP concentrati...

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Detalhes bibliográficos
Publicado no:Nature
Main Authors: Küffer, Alexander, Lakkaraju, Asvin KK, Mogha, Amit, Petersen, Sarah C., Airich, Kristina, Doucerain, Cédric, Marpakwar, Rajlakshmi, Bakirci, Pamela, Senatore, Assunta, Monnard, Arnaud, Schiavi, Carmen, Nuvolone, Mario, Grosshans, Bianka, Hornemann, Simone, Bassilana, Frederic, Monk, Kelly R., Aguzzi, Adriano
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5499706/
https://ncbi.nlm.nih.gov/pubmed/27501152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature19312
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