Nodal patterning without Lefty inhibitory feedback is functional but fragile

Developmental signaling pathways often activate their own inhibitors. Such inhibitory feedback has been suggested to restrict the spatial and temporal extent of signaling or mitigate signaling fluctuations, but these models are difficult to rigorously test. Here, we determine whether the ability of...

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Bibliografiska uppgifter
I publikationen:eLife
Huvudupphovsmän: Rogers, Katherine W, Lord, Nathan D, Gagnon, James A, Pauli, Andrea, Zimmerman, Steven, Aksel, Deniz C, Reyon, Deepak, Tsai, Shengdar Q, Joung, J Keith, Schier, Alexander F
Materialtyp: Artigo
Språk:Inglês
Publicerad: eLife Sciences Publications, Ltd 2017
Ämnen:
Developmental Biology and Stem Cells
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5720593/
https://ncbi.nlm.nih.gov/pubmed/29215332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.28785
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