Nodal patterning without Lefty inhibitory feedback is functional but fragile

Developmental signaling pathways often activate their own inhibitors. Such inhibitory feedback has been suggested to restrict the spatial and temporal extent of signaling or mitigate signaling fluctuations, but these models are difficult to rigorously test. Here, we determine whether the ability of...

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Detaylı Bibliyografya
Yayımlandı:eLife
Asıl Yazarlar: Rogers, Katherine W, Lord, Nathan D, Gagnon, James A, Pauli, Andrea, Zimmerman, Steven, Aksel, Deniz C, Reyon, Deepak, Tsai, Shengdar Q, Joung, J Keith, Schier, Alexander F
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: eLife Sciences Publications, Ltd 2017
Konular:
Developmental Biology and Stem Cells
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5720593/
https://ncbi.nlm.nih.gov/pubmed/29215332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.28785
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