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STR profiling and Copy Number Variation analysis on single, preserved cells using current Whole Genome Amplification methods

The growing interest in liquid biopsies for cancer research and cell-based non-invasive prenatal testing (NIPT) invigorates the need for improved single cell analysis. In these applications, target cells are extremely rare and fragile in peripheral circulation, which makes the genetic analysis very...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Vander Plaetsen, Ann-Sophie, Deleye, Lieselot, Cornelis, Senne, Tilleman, Laurentijn, Van Nieuwerburgh, Filip, Deforce, Dieter
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5719346/
https://ncbi.nlm.nih.gov/pubmed/29215049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-17525-5
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