Performance of a TthPrimPol-based whole genome amplification kit for copy number alteration detection using massively parallel sequencing

Starting from only a few cells, current whole genome amplification (WGA) methods provide enough DNA to perform massively parallel sequencing (MPS). Unfortunately, all current WGA methods introduce representation bias which limits detection of copy number aberrations (CNAs) smaller than 3 Mb. A recen...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Deleye, Lieselot, De Coninck, Dieter, Dheedene, Annelies, De Sutter, Petra, Menten, Björn, Deforce, Dieter, Van Nieuwerburgh, Filip
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4992833/
https://ncbi.nlm.nih.gov/pubmed/27546482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep31825
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