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Performance of four modern whole genome amplification methods for copy number variant detection in single cells

Whole genome amplification (WGA) has become an invaluable tool to perform copy number variation (CNV) detection in single, or a limited number of cells. Unfortunately, current WGA methods introduce representation bias that limits the detection of small CNVs. New WGA methods have been introduced that...

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Bibliografske podrobnosti
izdano v:Sci Rep
Main Authors: Deleye, Lieselot, Tilleman, Laurentijn, Vander Plaetsen, Ann-Sophie, Cornelis, Senne, Deforce, Dieter, Van Nieuwerburgh, Filip
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2017
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5469777/
https://ncbi.nlm.nih.gov/pubmed/28611458
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-03711-y
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