Structural and functional analyses of the mammalian TIN2-TPP1-TRF2 telomeric complex

Telomeres are nucleoprotein complexes that play essential roles in protecting chromosome ends. Mammalian telomeres consist of repetitive DNA sequences bound by the shelterin complex. In this complex, the POT1-TPP1 heterodimer binds to single-stranded telomeric DNAs, while TRF1 and TRF2-RAP1 interact...

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Publicat a:Cell Res
Autors principals: Hu, Chunyi, Rai, Rekha, Huang, Chenhui, Broton, Cayla, Long, Juanjuan, Xu, Ying, Xue, Jing, Lei, Ming, Chang, Sandy, Chen, Yong
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2017
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5717407/
https://ncbi.nlm.nih.gov/pubmed/29160297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2017.144
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