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NBS1 phosphorylation status dictates repair choice of dysfunctional telomeres
Telomeres employ TRF2 to protect chromosome ends from activating the DNA damage sensor MRE11-RAD50-NBS1 (MRN), thereby repressing ATM-dependent DNA damage checkpoint responses. How TRF2 prevents MRN activation at dysfunctional telomeres is unclear. Here, we show that the phosphorylation status of NB...
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| Publié dans: | Mol Cell |
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| Auteurs principaux: | , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2017
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5639704/ https://ncbi.nlm.nih.gov/pubmed/28216226 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2017.01.016 |
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