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Structural and functional analyses of the mammalian TIN2-TPP1-TRF2 telomeric complex

Telomeres are nucleoprotein complexes that play essential roles in protecting chromosome ends. Mammalian telomeres consist of repetitive DNA sequences bound by the shelterin complex. In this complex, the POT1-TPP1 heterodimer binds to single-stranded telomeric DNAs, while TRF1 and TRF2-RAP1 interact...

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Detalhes bibliográficos
Publicado no:Cell Res
Main Authors: Hu, Chunyi, Rai, Rekha, Huang, Chenhui, Broton, Cayla, Long, Juanjuan, Xu, Ying, Xue, Jing, Lei, Ming, Chang, Sandy, Chen, Yong
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5717407/
https://ncbi.nlm.nih.gov/pubmed/29160297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2017.144
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