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Structural and functional analyses of the mammalian TIN2-TPP1-TRF2 telomeric complex
Telomeres are nucleoprotein complexes that play essential roles in protecting chromosome ends. Mammalian telomeres consist of repetitive DNA sequences bound by the shelterin complex. In this complex, the POT1-TPP1 heterodimer binds to single-stranded telomeric DNAs, while TRF1 and TRF2-RAP1 interact...
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Publicado no: | Cell Res |
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Main Authors: | , , , , , , , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
Nature Publishing Group
2017
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5717407/ https://ncbi.nlm.nih.gov/pubmed/29160297 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2017.144 |
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