Identification of coexistence of BRAF V600E mutation and EZH2 gain specifically in melanoma as a promising target for combination therapy

BACKGROUND: Coexistence of enhancer of zeste homolog 2 (EZH2) and BRAF gene aberrations has been described in many cancer types. In this study, we aim to explore the coexistence status of BRAF V600E mutation and the copy number variation of EZH2 and explore the potential of this combination as a the...

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Detalhes bibliográficos
Publicado no:J Transl Med
Main Authors: Yu, Huan, Ma, Meng, Yan, Junya, Xu, Longwen, Yu, Jiayi, Dai, Jie, Xu, Tianxiao, Tang, Huan, Wu, Xiaowen, Li, Siming, Lian, Bin, Mao, Lili, Chi, Zhihong, Cui, Chuanliang, Guo, Jun, Kong, Yan
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2017
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5716227/
https://ncbi.nlm.nih.gov/pubmed/29202777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-017-1344-z
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