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Genome-wide prediction of minor-groove electrostatic potential enables biophysical modeling of protein–DNA binding

Protein–DNA binding is a fundamental component of gene regulatory processes, but it is still not completely understood how proteins recognize their target sites in the genome. Besides hydrogen bonding in the major groove (base readout), proteins recognize minor-groove geometry using positively charg...

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Bibliografiska uppgifter
I publikationen:Nucleic Acids Res
Huvudupphovsmän: Chiu, Tsu-Pei, Rao, Satyanarayan, Mann, Richard S., Honig, Barry, Rohs, Remo
Materialtyp: Artigo
Språk:Inglês
Publicerad: Oxford University Press 2017
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5716191/
https://ncbi.nlm.nih.gov/pubmed/29040720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx915
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