Design, Synthesis, and Evaluation of Ribose-Modified Anilinopyrimidine Derivatives as EGFR Tyrosine Kinase Inhibitors

The synthesis of a series of ribose-modified anilinopyrimidine derivatives was efficiently achieved by utilizing DBU or tBuOLi-promoted coupling of ribosyl alcohols with 2,4,5-trichloropyrimidine as key step. Preliminary biological evaluation of this type of compounds as new EGFR tyrosine kinase inh...

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Detalhes bibliográficos
Publicado no:Front Chem
Main Authors: Hu, Xiuqin, Wang, Disha, Tong, Yi, Tong, Linjiang, Wang, Xia, Zhu, Lili, Xie, Hua, Li, Shiliang, Yang, You, Xu, Yufang
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2017
Assuntos:
Chemistry
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5715404/
https://ncbi.nlm.nih.gov/pubmed/29250520
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fchem.2017.00101
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