Discovery of Potent and Noncovalent Reversible EGFR Kinase Inhibitors of EGFR(L858R/T790M/C797S)

[Image: see text] In this paper, we describe the discovery and optimization of a series of noncovalent reversible epidermal growth factor receptor inhibitors of EGFR(L858R/T790M/C797S). One of the most promising compounds, 25g, inhibited the enzymatic activity of EGFR(L858R/T790M/C797S) with an IC(5...

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Veröffentlicht in:ACS Med Chem Lett
Hauptverfasser: Li, Qiannan, Zhang, Tao, Li, Shiliang, Tong, Linjiang, Li, Junyu, Su, Zhicheng, Feng, Fang, Sun, Deheng, Tong, Yi, Wang, Xia, Zhao, Zhenjiang, Zhu, Lili, Ding, Jian, Li, Honglin, Xie, Hua, Xu, Yufang
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Chemical Society 2019
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6580378/
https://ncbi.nlm.nih.gov/pubmed/31223440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.8b00564
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