Scalable synthesis of bryostatin 1 and analogs, adjuvant leads against latent HIV

Bryostatin 1 is an exceedingly scarce marine-derived natural product that is in clinical development directed at HIV/AIDS eradication, cancer immunotherapy, and the treatment of Alzheimer’s disease. Despite this unique portfolio of indications, its availability has been limited and variable, thus im...

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Vydáno v:Science
Hlavní autoři: Wender, Paul A., Hardman, Clayton T., Ho, Stephen, Jeffreys, Matthew S., Maclaren, Jana K., Quiroz, Ryan V., Ryckbosch, Steven M., Shimizu, Akira J., Sloane, Jack L., Stevens, Matthew C.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5714505/
https://ncbi.nlm.nih.gov/pubmed/29026042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aan7969
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