Generation and CRISPR/Cas9 editing of transformed progenitor B cells as a pseudo-physiological system to study DNA repair gene function in V(D)J recombination

Antigen receptor gene assembly is accomplished in developing lymphocytes by the V(D)J recombination reaction, which can be separated into two steps: DNA cleavage by the recombination-activating gene (RAG) nuclease and joining of DNA double strand breaks (DSBs) by components of the nonhomologous end...

Full beskrivning

Sparad:
Bibliografiska uppgifter
I publikationen:J Immunol Methods
Huvudupphovsmän: Lenden Hasse, Hélène, Lescale, Chloé, Bianchi, Joy J., Yu, Wei, Bedora-Faure, Marie, Deriano, Ludovic
Materialtyp: Artigo
Språk:Inglês
Publicerad: Elsevier 2017
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5714433/
https://ncbi.nlm.nih.gov/pubmed/28882611
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jim.2017.08.007
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk