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Breakage-Fusion-Bridge Events Trigger Complex Genome Rearrangements and Amplifications in Developmentally Arrested T Cell Lymphomas
To reveal the relative contribution of the recombination activating gene (RAG)1/2 nuclease to lymphomagenesis, we conducted a genome-wide analysis of T cell lymphomas from p53-deficient mice expressing or lacking RAG2. We found that while p53(−/−) lymphoblastic T cells harbor primarily ectopic DNA d...
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| Publié dans: | Cell Rep |
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| Auteurs principaux: | , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Cell Press
2019
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6581794/ https://ncbi.nlm.nih.gov/pubmed/31167132 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.05.014 |
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