Generation and CRISPR/Cas9 editing of transformed progenitor B cells as a pseudo-physiological system to study DNA repair gene function in V(D)J recombination

Antigen receptor gene assembly is accomplished in developing lymphocytes by the V(D)J recombination reaction, which can be separated into two steps: DNA cleavage by the recombination-activating gene (RAG) nuclease and joining of DNA double strand breaks (DSBs) by components of the nonhomologous end...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Immunol Methods
Prif Awduron: Lenden Hasse, Hélène, Lescale, Chloé, Bianchi, Joy J., Yu, Wei, Bedora-Faure, Marie, Deriano, Ludovic
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Elsevier 2017
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5714433/
https://ncbi.nlm.nih.gov/pubmed/28882611
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jim.2017.08.007
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