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Generation and CRISPR/Cas9 editing of transformed progenitor B cells as a pseudo-physiological system to study DNA repair gene function in V(D)J recombination

Antigen receptor gene assembly is accomplished in developing lymphocytes by the V(D)J recombination reaction, which can be separated into two steps: DNA cleavage by the recombination-activating gene (RAG) nuclease and joining of DNA double strand breaks (DSBs) by components of the nonhomologous end...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:J Immunol Methods
Päätekijät: Lenden Hasse, Hélène, Lescale, Chloé, Bianchi, Joy J., Yu, Wei, Bedora-Faure, Marie, Deriano, Ludovic
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Elsevier 2017
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5714433/
https://ncbi.nlm.nih.gov/pubmed/28882611
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jim.2017.08.007
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