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Combinatorics of the Breakage-Fusion-Bridge Mechanism
The breakage-fusion-bridge (BFB) mechanism was proposed over seven decades ago and is a source of genomic variability and gene amplification in cancer. Here we formally model and analyze the BFB mechanism, to our knowledge the first time this has been undertaken. We show that BFB can be modeled as s...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Mary Ann Liebert, Inc.
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3375649/ https://ncbi.nlm.nih.gov/pubmed/22506505 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/cmb.2012.0020 |
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