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An algorithmic approach for breakage-fusion-bridge detection in tumor genomes

Breakage-fusion-bridge (BFB) is a mechanism of genomic instability characterized by the joining and subsequent tearing apart of sister chromatids. When this process is repeated during multiple rounds of cell division, it leads to patterns of copy number increases of chromosomal segments as well as f...

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Библиографические подробности
Главные авторы: Zakov, Shay, Kinsella, Marcus, Bafna, Vineet
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2013
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3619374/
https://ncbi.nlm.nih.gov/pubmed/23503850
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1220977110
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