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Sensitive gene fusion detection using ambiguously mapping RNA-Seq read pairs

Motivation: Paired-end whole transcriptome sequencing provides evidence for fusion transcripts. However, due to the repetitiveness of the transcriptome, many reads have multiple high-quality mappings. Previous methods to find gene fusions either ignored these reads or required additional longer sing...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Kinsella, Marcus, Harismendy, Olivier, Nakano, Masakazu, Frazer, Kelly A., Bafna, Vineet
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2011
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3072550/
https://ncbi.nlm.nih.gov/pubmed/21330288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bioinformatics/btr085
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