Single-chromosome Gains Commonly Function as Tumor Suppressors

Aneuploidy is a hallmark of cancer, although its effects on tumorigenesis are unclear. Here, we investigated the relationship between aneuploidy and cancer development using cells engineered to harbor single extra chromosomes. We found that nearly all trisomic cell lines grew poorly in vitro and as...

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Опубликовано в: :Cancer Cell
Главные авторы: Sheltzer, Jason M., Ko, Julie H., Replogle, John M., Burgos, Nicole C. Habibe, Chung, Erica S., Meehl, Colleen M., Sayles, Nicole M., Passerini, Verena, Storchova, Zuzana, Amon, Angelika
Формат: Artigo
Язык:Inglês
Опубликовано: 2017
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5713901/
https://ncbi.nlm.nih.gov/pubmed/28089890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2016.12.004
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