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Single-chromosome Gains Commonly Function as Tumor Suppressors
Aneuploidy is a hallmark of cancer, although its effects on tumorigenesis are unclear. Here, we investigated the relationship between aneuploidy and cancer development using cells engineered to harbor single extra chromosomes. We found that nearly all trisomic cell lines grew poorly in vitro and as...
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| Publicado no: | Cancer Cell |
|---|---|
| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5713901/ https://ncbi.nlm.nih.gov/pubmed/28089890 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2016.12.004 |
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