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Single-chromosome Gains Commonly Function as Tumor Suppressors
Aneuploidy is a hallmark of cancer, although its effects on tumorigenesis are unclear. Here, we investigated the relationship between aneuploidy and cancer development using cells engineered to harbor single extra chromosomes. We found that nearly all trisomic cell lines grew poorly in vitro and as...
में बचाया:
| में प्रकाशित: | Cancer Cell |
|---|---|
| मुख्य लेखकों: | , , , , , , , , , |
| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
2017
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5713901/ https://ncbi.nlm.nih.gov/pubmed/28089890 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2016.12.004 |
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