Safety and efficacy of intratumoral injections of chimeric antigen receptor (CAR) T cells in metastatic breast cancer

Chimeric antigen receptors (CARs) are synthetic molecules that provide new specificities to T cells. Although successful in treatment of hematologic malignancies, CAR T cells are ineffective for solid tumors to date. We found that the cell-surface molecule c-Met was expressed in ~50% of breast tumor...

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Publicado en:Cancer Immunol Res
Autores principales: Tchou, Julia, Zhao, Yangbing, Levine, Bruce L, Zhang, Paul J, Davis, Megan M, Melenhorst, Jan Joseph, Kulikovskaya, Irina, Brennan, Andrea L, Liu, Xiaojun, Lacey, Simon F, Posey, Avery, Williams, Austin D, So, Alycia, Conejo-Garcia, Jose R, Plesa, Gabriela, Young, Regina M., McGettigan, Shannon, Campbell, Jean, Pierce, Robert H, Matro, Jennifer M, DeMichele, Angela M, Clark, Amy S, Cooper, Laurence J, Schuchter, Lynn M., Vonderheide, Robert H, June, Carl H
Formato: Artigo
Lenguaje:Inglês
Publicado: 2017
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5712264/
https://ncbi.nlm.nih.gov/pubmed/29109077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2326-6066.CIR-17-0189
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