Activity of Mesothelin-specific Chimeric Antigen Receptor T cells Against Pancreatic Carcinoma Metastases in a Phase 1 Trial

Pancreatic ductal adenocarcinoma (PDAC) is resistant to T-cell mediated immunotherapy. We engineered T cells to transiently express an mRNA encoding a chimeric antigen receptor (CAR) specific for mesothelin—a protein that is over-expressed by PDAC cells. We performed a phase 1 study to evaluate the...

Volledige beschrijving

Bewaard in:
Bibliografische gegevens
Gepubliceerd in:Gastroenterology
Hoofdauteurs: Beatty, Gregory L., O’Hara, Mark H., Lacey, Simon F., Torigian, Drew A., Nazimuddin, Farzana, Chen, Fang, Kulikovskaya, Irina M., Soulen, Michael C., McGarvey, Maureen, Nelson, Anne Marie, Gladney, Whitney L., Levine, Bruce L., Melenhorst, J. Joseph, Plesa, Gabriela, June, Carl H.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2018
Onderwerpen:
Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6035088/
https://ncbi.nlm.nih.gov/pubmed/29567081
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2018.03.029
Tags: Voeg label toe
Geen labels, Wees de eerste die dit record labelt!

Gelijkaardige items