Dual Targeting of Mesothelin and CD19 with Chimeric Antigen Receptor-Modified T Cells in Patients with Metastatic Pancreatic Cancer

B cells infiltrate pancreatic ductal adenocarcinoma (PDAC) and in preclinical cancer models, can suppress T cell immunosurveillance in cancer. Here, we conducted a pilot study to assess the safety and feasibility of administering lentiviral-transduced chimeric antigen receptor (CAR)-modified autolog...

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Detalhes bibliográficos
Publicado no:Mol Ther
Main Authors: Ko, Andrew H., Jordan, Alexander C., Tooker, Evan, Lacey, Simon F., Chang, Renee B., Li, Yan, Venook, Alan P., Tempero, Margaret, Damon, Lloyd, Fong, Lawrence, O’Hara, Mark H., Levine, Bruce L., Melenhorst, J. Joseph, Plesa, Gabriela, June, Carl H., Beatty, Gregory L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Gene & Cell Therapy 2020
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7647666/
https://ncbi.nlm.nih.gov/pubmed/32730744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2020.07.017
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