Dual Targeting of Mesothelin and CD19 with Chimeric Antigen Receptor-Modified T Cells in Patients with Metastatic Pancreatic Cancer

B cells infiltrate pancreatic ductal adenocarcinoma (PDAC) and in preclinical cancer models, can suppress T cell immunosurveillance in cancer. Here, we conducted a pilot study to assess the safety and feasibility of administering lentiviral-transduced chimeric antigen receptor (CAR)-modified autolog...

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Udgivet i:Mol Ther
Main Authors: Ko, Andrew H., Jordan, Alexander C., Tooker, Evan, Lacey, Simon F., Chang, Renee B., Li, Yan, Venook, Alan P., Tempero, Margaret, Damon, Lloyd, Fong, Lawrence, O’Hara, Mark H., Levine, Bruce L., Melenhorst, J. Joseph, Plesa, Gabriela, June, Carl H., Beatty, Gregory L.
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Gene & Cell Therapy 2020
Fag:
Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7647666/
https://ncbi.nlm.nih.gov/pubmed/32730744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2020.07.017
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