Identification of chimeric antigen receptors that mediate constitutive or inducible proliferation of T cells

This study compared second generation chimeric antigen receptors encoding signaling domains composed of CD28, ICOS and 4-1BB. Here we report that certain CARs endow T cells with the ability to undergo long-term autonomous proliferation. Transduction of primary human T-cell with lentiviral vectors en...

詳細記述

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書誌詳細
出版年:Cancer Immunol Res
主要な著者: Frigault, Matthew J, Lee, Jihyun, Basil, Maria Ciocca, Carpenito, Carmine, Motohashi, Shinichiro, Scholler, John, Kawalekar, Omkar U., Guedan, Sonia, McGettigan, Shannon E., Posey, Avery D., Ang, Sonny, Cooper, Laurence J. N., Platt, Jesse M., Johnson, F. Brad, Paulos, Chrystal M, Zhao, Yangbing, Kalos, Michael, Milone, Michael C., June, Carl H.
フォーマット: Artigo
言語:Inglês
出版事項: 2015
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4390458/
https://ncbi.nlm.nih.gov/pubmed/25600436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2326-6066.CIR-14-0186
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