Identification of chimeric antigen receptors that mediate constitutive or inducible proliferation of T cells

This study compared second generation chimeric antigen receptors encoding signaling domains composed of CD28, ICOS and 4-1BB. Here we report that certain CARs endow T cells with the ability to undergo long-term autonomous proliferation. Transduction of primary human T-cell with lentiviral vectors en...

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Bibliografiske detaljer
Udgivet i:Cancer Immunol Res
Main Authors: Frigault, Matthew J, Lee, Jihyun, Basil, Maria Ciocca, Carpenito, Carmine, Motohashi, Shinichiro, Scholler, John, Kawalekar, Omkar U., Guedan, Sonia, McGettigan, Shannon E., Posey, Avery D., Ang, Sonny, Cooper, Laurence J. N., Platt, Jesse M., Johnson, F. Brad, Paulos, Chrystal M, Zhao, Yangbing, Kalos, Michael, Milone, Michael C., June, Carl H.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4390458/
https://ncbi.nlm.nih.gov/pubmed/25600436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2326-6066.CIR-14-0186
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