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Enhancing CAR T cell persistence through ICOS and 4-1BB costimulation
Successful tumor eradication by chimeric antigen receptor–expressing (CAR-expressing) T lymphocytes depends on CAR T cell persistence and effector function. We hypothesized that CD4(+) and CD8(+) T cells may exhibit distinct persistence and effector phenotypes, depending on the identity of specific...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | JCI Insight |
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| Κύριοι συγγραφείς: | , , , , , , , , , , , , , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
American Society for Clinical Investigation
2018
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5821198/ https://ncbi.nlm.nih.gov/pubmed/29321369 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.96976 |
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