Enhancing CAR T cell persistence through ICOS and 4-1BB costimulation

Successful tumor eradication by chimeric antigen receptor–expressing (CAR-expressing) T lymphocytes depends on CAR T cell persistence and effector function. We hypothesized that CD4(+) and CD8(+) T cells may exhibit distinct persistence and effector phenotypes, depending on the identity of specific...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Guedan, Sonia, Posey, Avery D., Shaw, Carolyn, Wing, Anna, Da, Tong, Patel, Prachi R., McGettigan, Shannon E., Casado-Medrano, Victoria, Kawalekar, Omkar U., Uribe-Herranz, Mireia, Song, Decheng, Melenhorst, J. Joseph, Lacey, Simon F., Scholler, John, Keith, Brian, Young, Regina M., June, Carl H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5821198/
https://ncbi.nlm.nih.gov/pubmed/29321369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.96976
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