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4-1BB costimulation promotes CAR T cell survival through noncanonical NF-κB signaling
Clinical response to chimeric antigen receptor (CAR) T cell therapy is correlated with CAR T cell persistence, especially for CAR T cells that target CD19(+) hematologic malignancies. 4-1BB–costimulated CAR (BBζ) T cells exhibit longer persistence after adoptive transfer than do CD28-costimulated CA...
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Foilsithe in: | Sci Signal |
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Main Authors: | , , , , , |
Formáid: | Artigo |
Teanga: | Inglês |
Foilsithe: |
2020
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Ábhair: | |
Rochtain Ar Líne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7883633/ https://ncbi.nlm.nih.gov/pubmed/32234960 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aay8248 |
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