Safety and efficacy of intratumoral injections of chimeric antigen receptor (CAR) T cells in metastatic breast cancer

Chimeric antigen receptors (CARs) are synthetic molecules that provide new specificities to T cells. Although successful in treatment of hematologic malignancies, CAR T cells are ineffective for solid tumors to date. We found that the cell-surface molecule c-Met was expressed in ~50% of breast tumor...

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Publicado no:Cancer Immunol Res
Main Authors: Tchou, Julia, Zhao, Yangbing, Levine, Bruce L, Zhang, Paul J, Davis, Megan M, Melenhorst, Jan Joseph, Kulikovskaya, Irina, Brennan, Andrea L, Liu, Xiaojun, Lacey, Simon F, Posey, Avery, Williams, Austin D, So, Alycia, Conejo-Garcia, Jose R, Plesa, Gabriela, Young, Regina M., McGettigan, Shannon, Campbell, Jean, Pierce, Robert H, Matro, Jennifer M, DeMichele, Angela M, Clark, Amy S, Cooper, Laurence J, Schuchter, Lynn M., Vonderheide, Robert H, June, Carl H
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5712264/
https://ncbi.nlm.nih.gov/pubmed/29109077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2326-6066.CIR-17-0189
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