Sleeping Beauty insertional mutagenesis in mice identifies drivers of steatosis-associated hepatic tumor

Hepatic steatosis is a strong risk factor for the development of hepatocellular carcinoma (HCC), yet little is known about the molecular pathology associated with this factor. In this study, we performed a forward genetic screen using Sleeping Beauty (SB) transposon insertional mutagenesis in mice t...

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Publicat a:Cancer Res
Autors principals: Tschida, Barbara R., Temiz, Nuri A., Kuka, Timothy P., Lee, Lindsey A., Riordan, Jesse D., Tierrablanca, Carlos A., Hullsiek, Robert, Wagner, Sandra, Hudson, Wendy A., Linden, Michael A., Amin, Khalid, Beckmann, Pauline J., Heuer, Rachel A., Sarver, Aaron L., Yang, Ju Dong, Roberts, Lewis R., Nadeau, Joseph H., Dupuy, Adam J., Keng, Vincent W., Largaespada, David A.
Format: Artigo
Idioma:Inglês
Publicat: 2017
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5712258/
https://ncbi.nlm.nih.gov/pubmed/28993411
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-17-2281
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