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Insertional mutagenesis using the Sleeping Beauty transposon system identifies drivers of erythroleukemia in mice
Insertional mutagenesis is a powerful means of identifying cancer drivers in animal models. We used the Sleeping Beauty (SB) transposon/transposase system to identify activated oncogenes in hematologic cancers in wild-type mice and mice that express a stabilized cyclin E protein (termed cyclin ET74A...
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| Publicado no: | Sci Rep |
|---|---|
| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6445099/ https://ncbi.nlm.nih.gov/pubmed/30940846 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-41805-x |
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