Antisense transcription of the myotonic dystrophy locus yields low-abundant RNAs with and without (CAG)n repeat

The unstable (CTG·CAG)n trinucleotide repeat in the myotonic dystrophy type 1 (DM1) locus is bidirectionally transcribed from genes with terminal overlap. By transcription in the sense direction, the DMPK gene produces various alternatively spliced mRNAs with a (CUG)n repeat in their 3′ UTR. Express...

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Detalhes bibliográficos
Publicado no:RNA Biol
Main Authors: Gudde, Anke E. E. G., van Heeringen, Simon J., de Oude, Amanda I., van Kessel, Ingeborg D. G., Estabrook, Joseph, Wang, Eric T., Wieringa, Bé, Wansink, Derick G.
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5711456/
https://ncbi.nlm.nih.gov/pubmed/28102759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15476286.2017.1279787
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